Seminar

Multiphoton Microfabrication Platform - Effect of Mechanical Asymmetry in Stem Cell Niche on Asymmetric Cell Division (ACD)

Speaker

Mr. Chan Chun Hin Chris

PhD candidate in the Mechanical Engineering Dept.

Date & Time

Thursday, 28 April 2022

2:30 am

Venue

Via Zoom

Abstract:

Asymmetric cell division (ACD) is an essential process in stem cells in which cells divide into two daughter cells with different cellular fates. In such way the stem cell pool can maintain its cell renewal ability, but at the same time give rise to lineage-specific cells. The segregation of cell fate determinant is an important mechanism of the process. It is known that stem cells ACD is also highly dependent on the stem cell niche, where cells are able to sense the mechanical signals from the underlying niche and regulate cell behaviors. The Multiphoton Microfabrication and Micropatterning (MMM) platform established by the HKU Tissue Engineering Lab is able to construct engineered cell niche with controllable niche factors including the mechanical properties, topological features and ECM components. This study employs the MMM platform and aims to microfabricate structures consisting of microwells and pillars with controllable patterns of mechanical properties (elastic modulus and stiffness) in the scale of a single cell approach to investigate the effect of mechanical asymmetry in stem cell niche on mouse embryonic stem cells.

Research Areas:

Biomedical Engineering

Contact for

Information

Prof. B. Chan

+(852) 3917 2632

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